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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T18321 | Mc-Val-Cit-PAB-Cl | Others | |
Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC5... | |||
T5149 | MC-Val-Cit-PAB | Others , AChR | |
MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker. | |||
T77847 | MC-Val-Cit-PAB-Exatecan | MC-Val-Cit-PAB-DX8951 | |
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a conjugate of the DNA topoisomerase I inhibitor DX-8951 and a cathepsin-cleavable antibody-drug conjugate (ADC) linker, designed for targeted cancer therapy application... | |||
T18320 | MC-Val-Cit-PAB-carfilzomib iodide | MC-Val-Cit-PAB-carfilzomib | Others |
MC-Val-Cit-PAB-carfilzomib is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADC), comprising the irreversible proteasome inhibitor carfilzomib, connected through the ADC linker MC-Val-Cit-PAB. | |||
T18324 | MC-Val-Cit-PAB-duocarmycin chloride | MC-Val-Cit-PAB-duocarmycin | Others |
MC-Val-Cit-PAB-duocarmycin is an antibody-drug conjugate (ADC) linker that combines duocarmycin, a potent DNA minor groove-binding alkylating agent, with an antitumor drug through the MC-Val-Cit-PAB linker, exhibiting si... | |||
T33243 | MC-Val-Cit-PAB-VX765 | Belnacasan-conjugate,VX765-conjugate,MC-Val-Cit-PABC-VX765 | |
MC-VAL-CIT-PAB-VX765 or MC-VAL-CIT-PABC-VX765 is a VX765 derivative that can be conjugated to antibodies, proteins, or polymers for targeted drug delivery. MC-Val- CIT -PAB is a cathepsin cleavable ADC connector, which h... | |||
T18323 | MC-Val-Cit-PAB-dimethylDNA31 | Others | |
MC-Val-Cit-PAB-dimethylDNA31 is a drug-linker conjugate employed in antibody-drug conjugates (ADCs) that exhibits robust antitumor efficacy. This conjugate utilizes the ADC linker, MC-Val-Cit-PAB, to link to the potent a... | |||
T18330 | MC-Val-Cit-PAB-vinblastine | Others | |
MC-Val-Cit-PAB-vinblastine is a potent antitumor drug-linker conjugate for Antibody-Drug Conjugates (ADC), featuring vinblastine (a microtubule protein inhibitor) connected through the MC-Val-Cit-PAB ADC linker. | |||
T18327 | MC-Val-Cit-PAB-Retapamulin | Others | |
MC-Val-Cit-PAB-Retapamulin is a drug-linker conjugate for antibody-drug conjugates (ADC) that exhibits potent antitumor activity. This compound utilizes Retapamulin, a ribosome inhibitor, connected through the ADC linker... | |||
T18326 | MC-Val-Cit-PAB-MMAF | Others | |
MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavabl... | |||
T18325 | MC-Val-Cit-PAB-Indibulin | Others | |
MC-Val-Cit-PAB-Indibulin is an antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), featuring the orally active tubulin assembly inhibitor, Indibulin, connected through the MC-Val-Cit-PAB ADC linker. This... | |||
T18328 | MC-Val-Cit-PAB-rifabutin | Others | |
MC-Val-Cit-PAB-rifabutin is a drug-linker conjugate designed for antibody-drug conjugates (ADC), featuring the potent antitumor agent rifabutin (a DNA-dependent RNA polymerase inhibitor) connected through the MC-Val-Cit-... | |||
T18322 | MC-Val-Cit-PAB-clindamycin | Others | |
MC-Val-Cit-PAB-clindamycin is an antibody-drug conjugate (ADC) linker that combines the potent antitumor properties of clindamycin, a protein synthesis inhibitor, with the ADC linker MC-Val-Cit-PAB, to enhance its abilit... | |||
T18319 | MC-Val-Cit-PAB-Auristatin E | Others | |
MC-Val-Cit-PAB-Auristatin E is an antibody-drug conjugate (ADC) linker compound featuring Auristatin E, a potent cytotoxic tubulin modifier, connected through the MC-Val-Cit-PAB linker, exhibiting significant antitumor a... | |||
T31567 | Doxorubicin-MVCP | MC-Val-Cit-PAB-Doxorubicin,MC-Val-Cit-PAB-Dox | |
Doxorubicin-MVCP (MC-Val-Cit-PAB-Doxorubicin) is a Doxorubicin derivative with an MC-Val-Cit-PAB linker. | |||
T18329 | MC-VC(S)-PABQ-Tubulysin M | MC-Val-Cit-PAB-tubulysin5a | Others |
MC-Val-Cit-PAB-tubulysin5a is a drug-linker conjugate for ADC with potent antitumor activity by using tubulysin5a (a tubulin inhibitor), linked via the ADC linker MC-Val-Cit-PAB. | |||
T77875 | Mc-Val-Cit-PAB-Gefitinib chloride | ||
Mc-Val-Cit-PAB-Gefitinib chloride is a conjugate agent-linker for antibody-drug conjugates (ADCs) that combines Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with the proprietary ADC li... | |||
T77826 | MC-Val-Cit-PAB-NH-C2-NH-Boc | ||
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin-cleavable ADC linker utilized in constructing antibody-drug conjugates (ADCs) [1]. | |||
T74468 | MC-Val-Cit-PAB-Amide-TLR7 agonist 4 | ||
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 (example 15) is a conjugate that acts as an immune agonist targeting both HER2-TLR7 and HER2-TLR8 pathways [1]. | |||
T33861 | Paclitaxel-MVCP | ||
Paclitaxel-MVCP ( MC-val-cit-pab-paclitaxel )is a paclitaxel derivative with an MC-Val-Cit-PAB linker, which can be used for the preparation of Paclitaxel conjugates for drug delivery and nanomedicine research. |